Cell Therapeutics Cancer Treatment Drug Candidate OPAXIO (formerly known as XYOTAX)

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border="0"></td> <td width="1"><img src="images/0.gif" width="1" height="1" alt="" border="0"></td> </tr> </table> </td> <td> </td> <td valign="TOP" class="a"> <br> <br> <table width="100%" border="0" cellspacing="0" cellpadding="0"> <tr valign="top"> <td colspan="2" class="a"> <h2>XYOTAX (paclitaxel poliglumex)</h2> <p><strong>XYOTAX™</strong> (pronounced Zi-o-taks) is a biologically-enhanced chemotherapeutic that links paclitaxel, the active ingredient in Taxol®, to a biodegradable <a href="about_technologies.htm" target="_parent">polyglutamate polymer</a>, which results in a new chemical entity.</p> <p>XYOTAX™ is intended to provide a potentially more effective treatment by delivering more paclitaxel to the tumor cells. When bound to the polymer, the chemotherapy is rendered inactive, potentially sparing normal tissue's exposure to high levels of unbound, active chemotherapy and its associated toxicities.</p> <p>Blood vessels in tumor tissue, unlike blood vessels in normal tissue, are porous to molecules like polyglutamate. Once inside the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Based on preclinical studies, it appears that XYOTAX™ is preferentially trapped in the tumor blood vessels allowing significantly more of the dose of chemotherapy to remain in the tumor.</p> <h1>XYOTAX™ Preclinical and Clinical Research</h1> We are currently studying XYOTAX in a number of clinical trials for the potential treatment of a variety of cancers including non-small cell lung (NSCLC) and ovarian cancer. </p> <p>Preclinical and clinical studies support that XYOTAX metabolism by lung cancer cells may be influenced by estrogen which could lead to enhanced release of paclitaxel and efficacy in women with lung cancer over non-biologically enhanced chemotherapeutic agents.</p> <p> </p></td> </tr> <tr> <td colspan="2" valign="TOP"><h1>XYOTAX™ Resources</h1> </td> </tr> <tr> <td valign="TOP" width="3%"> <font size="1"></font></td> <td valign="TOP" class="a" width="97%"><a href="pdf/XYOTAX-facts-4pg.pdf">XYOTAX Fact Sheet</a> (159k PDF) </td> </tr> <tr> <td valign="TOP" height="8" width="3%"> <font size="1"></font></td> <td valign="TOP" class="a" height="8" width="97%"><a href="pdf/PG-TXL_ref.pdf">XYOTAX References </a> (47k PDF) </td> </tr> <tr> <td valign="TOP"> <font size="1"></font></td> <td valign="TOP" class="a" height="27"> <p> <a href="video/Animat.mov" target="_blank">Quicktime video of polyglutamate technology and selective delivery of tumor-killing drug</a> (2mb)</p> </td> </tr> <tr> <td valign="TOP"><font size="1"></font></td> <td valign="TOP" class="a"><a href="prod_frame-cstudies-disease.htm">Clinical trials</a></td> </tr> <tr> <td valign="TOP"><font size="1"></font></td> <td valign="TOP" class="a"><a href="investors_news.htm" target="_parent">Press releases</a></td> </tr> <tr> <td valign="TOP"><font size="1"></font></td> <td valign="TOP" class="a"><a href="investors_sec.htm" target="_parent">SEC filings</a></td> </tr> </table> <p><span class="cr">Taxol® is a registered trademark of Bristol-Myers Squibb Co. </span><br> <br> <font class="cr">Posted Jan. 6, 2006</font><br> <br> <font class="cr">Copyright © 2004-2006 Cell Therapeutics, Inc., Seattle, WA, USA. All rights reserved. "Making cancer more treatable" is a registered mark of CTI.</font></p> <p><br>  </p></td> <td><img src="images/0.gif" width="5" height="128" alt="" border="0"></td> </tr> <tr> <td width="270" height="2"><img src="images/0.gif" width="270" height="1" alt="" border="0"></td> <td width="50" height="2"><img src="images/0.gif" width="50" height="1" alt="" border="0"></td> <td width="100%" height="2"><img src="images/0.gif" width="400" height="1" alt="" border="0"></td> <td width="50" height="2"><img src="images/0.gif" width="50" height="1" alt="" border="0"></td> </tr> </table> </body>